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Model TD-700 Press Releases

Introducing a program to grant Fluorometers to Life Science Researchers
Turner BioSystems announces a new program to grant fluorometers to applicants working in Life Sciences. The following instruments will be granted at no cost: TD-700 Laboratory Fluorometer, TBS-380 Mini-Fluorometer, and the Picofluor Handheld Fluorometer. These instruments are sensitive, versatile and easy to use and are backed by 30 years of the Turner experience in building sensitive, reliable instruments. These fluorometers are commonly used for measuring DNA, RNA, Proteins, Enzymes, Phosphatase, Protease, Green Fluorescent Protein, B-gal, and 4-MU. Sensitivity, specificity, and wide dynamic range are the advantages of using fluorescence over absorbance and other methods.

Caspace Protease Detection Using CaspACE™
Caspace-1 (ICE) and Caspace-3 (CPP32), cysteine aspartic acid specific proteases, have been shown to play key roles in inflammation and apoptosis in mammalian cells. Turner BioSystems TD-700 Laboratory Fluorometer combined with Promega Corporation's CaspACE^TM Assay System provide a highly sensitive, quantitative measurement of both ICE and CPP32 protease activities. The TD-700 Fluorometer provides sensitivity down to nM concentrations of AMC (7-amino-4-methylcoumarin) standard and has at least 4 decades of range.

Acid and Alkaline Phosphatase Detection Using DiFMUP
Fluorescence measurement of enzymes and enzymatic reactions is sensitive, fast, and inexpensive. The Turner BioSystems TD-700 Laboratory Fluorometer, using 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP), from Molecular Probes, enables quantitation as low as 1x10 -7 mg/mL (200pg) 4MU and has a linear range of over 5 orders of magnitude. The TD-700 Laboratory Fluorometer is a compact, easy-to-use benchtop instrument with multi-wavelength operation and multi-point calibration capabilities. In addition to protein phosphatase measurements, the instrument can be used in a variety of assays such as RNA or DNA quantitation, bacterial viability and cell proliferation studies, and gene expression measurements.

Solid Secondary Standards Now Available
Turner BioSystems, Inc. now offers solid secondary standards for use in various fluorometric analyses in the TD-700 Laboratory Fluorometer. After initial calibration with a primary standard, the solid standards may be used for future calibrations of the instrument, thereby eliminating the need to prepare daily standards. The standards, sealed in holders that fit directly into the TD-700 Laboratory Fluorometer's filter cylinder, are rugged pieces that can be stored on the shelf or in a drawer; no special handling is required. Standards are available for numerous assays using dyes such as Picogreen, Hoechst 33258 Dye, and Ethidium Bromide. Standards are ready to use upon arrrival.

New 100 µL Minicell Kit for Turner BioSystems Fluorometers
Turner BioSystems announces an easy, accurate, inexpensive way to quantitate 75-250 µL samples in disposable, borosilicate glass vials. The Minicell Adapter fits directly into a 10x10 mm holder. In addition to reducing reagent costs, the Minicell Kit gives you the optical quality of glass without possible contamination from reuse of more expensive, larger glass cuvettes. The Minicell Adapter is an excellent option for use with the TD-700 Laboratory Fluorometer. The multi-wavelength instrument is capable of quick, reliable, and accurate RNA/DNA quantitations, bacterial viability, cell proliferation, gene expression and protease activity studies.

RiboGreen™ for UltraSensitive RNA Quantitation
The Turner BioSystems TD-700 Laboratory Fluorometer, in combination with Molecular Probes’ new RiboGreen^TM RNA quantitation reagent, provides an ultrasensitive method for RNA quantitation in solution. This assay can detect as little as 1 ng/mL RNA, which is 1000-fold more sensitive than the most commonly used technique of measuring nucleic acid concentrations by absorbance at 260 nm (A260). Even in the presence of several compounds commonly found to contaminate nucleic acid preparations, the linear RNA assay range extends across three orders of magnitude. Although the RiboGreen reagent also binds to DNA, pretreatment of mixed samples with RNase-free DNase can be used to easily generate an RNA selective assay. The TD-700 Fluorometer is a compact, easy-to-use benchtop instrument equipped with a multi-assay filter cylinder and multi-point calibration capability. The instrument is designed for quick, reliable, and accurate measurements of RNA, DNA, proteins, GFP, and a variety of other fluorescent compounds.

Rapid & Sensitive LIVE/DEAD® Baclight^TM Bacterial Viability Assay
The Turner BioSystems TD-700 Laboratory Fluorometer, in combination with Molecular Probes’ LIVE/DEAD® Baclight™ Bacterial Viability Kit, provides a novel two-color fluorescence assay that will conveniently, rapidly and quantitatively distinguish live bacteria from dead bacteria in a mixed population of bacterial types. The kit utilizes mixtures of SYTO®9 green fluorescent nucleic acid stain and propidium iodide red fluorescent nucleic acid stain to produce green staining of live bacteria and red staining of dead bacteria. Consequently, the ratio of green to red fluorescence intensities provides a quantitative index of bacterial viability. The TD-700 Laboratory Fluorometer is a compact, easy-to-use benchtop instrument with a multi-wavelength operation and multi-point calibration capabilities. In addition to bacterial viability studies, the instrument is capable of quick, reliable, and accurate RNA, DNA, protein, and gene expression measurements.

Antibiotic Sensitivity Testing
The Turner BioSystems TD-700 Laboratory Fluorometer in combination with Molecular Probes SYTOX® Green Nucleic Acid Stain, provides a rapid and convenient alternative to traditional methods for assessment of bacterial sensitivity to antibiotics and a variety of bactericidal agents. The test-to-result period is substantially reduced because incubation is reduced from 18-48 hours to 1 hour. Also, bacterial viability can be continually monitored in real-time. The TD-700 Laboratory Fluorometer is a compact, easy-to-use benchtop instrument with multi-wavelength operation and multi-point calibration capabilities. In addition to antibiotic sensitivity testing, the instrument is capable of quick, reliable, and accurate RNA, DNA, protein, and GFP measurements.

Rapid & Sensitive Cell Density Determination
The Turner BioSystems TD-700 Laboratory Fluorometer in combination with Molecular Probes CyQUANT^™ Cell Proliferation Assay Kit provides a convenient, rapid, and sensitive procedure for determining the density of cells in culture. The assay is linear from 50 cells or fewer to at least 200,000 cells in a 2 mL volume, making it ideal for cell proliferation studies as well as routine cell counts. The TD-700 Laboratory Fluorometer is a compact, easy-to-use benchtop instrument with a multi-wavelength operation and multi-point calibration capabilities. In addition to cell density studies, the instrument is capable of quick, reliable, and accurate RNA, DNA, protein, and GFP measurements.

Accurate RNA Quantitation Down to 50 ng/mL
The Turner BioSystems TD-700 Laboratory Fluorometer has been shown to accurately quantitate ribonucleic acid (RNA) down to 50 ng/mL in a 2 ml buffer solution. The procedure, which uses ethidium bromide as the fluorochrome, is fast, simple, and can be performed using a minimum sample volume. The TD-700 Fluorometer is a compact, easy-to-use benchtop instrument equipped with a multi-assay filter cylinder and multi-point calibration. The instrument is designed for the quick, reliable, and accurate measurement of RNA, DNA, proteins, GFP, and a variety of other fluorescent compounds.

Turner BioSystems and CLONTECH Laboratories Offer GFP Quantitation Method
Turner BioSystems Inc., specialists in filter fluorometry for over 20 years, and CLONTECH Laboratories Inc., leading supplier of innovative tools for life science research, are pleased to offer researchers a simple and accurate method for Green Fluorescent Protein (GFP) quantitation. The method, created at Rutgers University, allows accurate quantitation of CLONTECH Laboratories' recombinant Aequorea GFP using the Turner BioSystems' TD-700 Laboratory Fluorometer. Using standard and sample fluorescence readings, volume of extract, and dilution factor, the amount of GFP induced in a particular exposure period can be easily and accurately calculated. The TD-700 Laboratory Fluorometer has a multi-assay filter cylinder which allows it to be easily configured for GFP quantitation as well as other fluorescence assays.

Turner BioSystems Fluorometer Accurately Quantitates Green-Fluorescent Protein
The Turner BioSystems TD-700 Laboratory Fluorometer quickly and accurately quantitates Aequorea victoria Green Fluorescent Protein (GFP), a fluorescent marker used to monitor gene expression in a variety of organisms. Unlike other reporters, GFP fluoresces in the absence of any other intrinsic or extrinsic proteins, substrates, or cofactors and its fluorescence is stable, species-independent and can be monitored non-invasively. The TD-700 Fluorometer is a compact, easy-to-use benchtop instrument equipped for the quick, reliable and accurate measurement of GFP and other fluorescent compounds. The fluorometer comes standard with a multi-assay filter cylinder, multi-point calibration and an RS232 serial interface.

A Fast, Simple, and Direct Method for Protease Detection
The Turner BioSystems TD-700 Laboratory Fluorometer and Molecular Probes' EnzChek™ Protease Assay Kit combine to provide a fast, simple, and direct method for the detection of metallo-, serine, acid, and sulfhydryl proteases. Traditional methods for protease detection involved precipitation, separatin, and pH adjustment protocols. The TD-700 EnzChek Assay method eliminates separation procedures and is up to 100 times more sensitive than the FTC-casein assay.The instrument-assay combination can be used to detect protease contamination of culture media, measure the kinetics of a variety of exo- and endopeptidases over a wide pH range, or measure total substrate turnover at a fixed time following addition of the enzyme. The TD-700 Fluorometer is equipped with menu-driven software, an RS-232 serial interace, multi-point calibration, and is easily configured for a wide variety of fluorescence-based assays.

Accurate DNA Quantitation Down to 25 picograms/mL
Using Turner BioSystems' TD-700 Laboratory Fluorometer and Molecular Probes' PicoGreen® Assay, ds DNA can be quantitated as low as 25 picograms/ml, even in the presence of RNA, proteins, and nucleotides. In addition, the fluorometer can be used with Hoechst 33258 Dye, Thiazole Orange, and other fluorescent dyes for low-level ds DNA quantitation. The TD-700 comes equipped with a quick-change filter cylinder, allowing the user to easily switch between assays and compare results. The TD-700 Laboratory Fluorometer is a compact, easy-to-use, benchtop instrument and comes standard with automatic range optimization, multi-point calibration, and ASCII data output.

Fluorescence Leaders Collaborate
Turner BioSystems, Inc., specialists in filter fluorometry for over 20 years, is pleased to announce its collaboration with Molecular Probes, Inc., world leaders in fluorescent reagent technology. Molecular Probes now offers the Turner BioSystems TD-700 Laboratory Fluorometer for use with their assays for proteins, nucleic acids and other biomolecules. Molecular Probes scientists found that in assays using a single pair of excitation/emission wavelengths, the quality of data produced by the TD-700 equals that obtainable with much more expensive spectrofluorometers.

New Laboratory Fluorometer Introduction!
January 1995: Turner BioSystems extends its family of reliable filter fluorometers by offering the Model TD-700 Laboratory Fluorometer. This compact, low-cost benchtop fluorometer features a unique quick-change filter cylinder, menu-driven software, an RS-232 serial interface, and multi-point calibration. A variety of compounds can be easily measured using application specific optical filters available from Turner BioSystems.