Product: Modulus™ Single Tube Multimode Reader
Product Series: Multimode Readers
Sample Format: 10 x 10 mm cuvette, 100 - 250 µl minicell vial (optional), 1.5 ml microfuge tube (luminescence)
Technologies: Luminescence, Fluorescence, and Absorbance

Modulus™ Single Tube Fluorometer

A modular, easy to use, and cost-effective single tube multimode reader for Luminescence, Fluorescence, and Absorbance Life Science applications.

"I have been using the Turner BioSystems fluorometer to measure DNA amounts from my chromatin immunoprecipitation methods. This instrument is perfect for our applications. It has a very small footprint and works like a charm when hooked up to the computer. Life in the lab would be very different without the instrument."
Tae Hoon Kim, Yale University School of Medicine

Overview

The Modulus™ Single Tube Multimode Reader is designed to provide the utmost flexibility. In addition to high performance, the Modulus™ blends user-friendly operation and a small footprint with flexible purchasing options. The result of this design is an instrument with superior performance that is easy to use, affordable, and can be customized to your laboratory’s needs.

Performance

The Modulus™ combines the superior performance expected from single-mode instruments with the functionality of multiple modes. To achieve high performance, the Modulus™ is designed with optical channels dedicated to each individual technology. Unlike other multimode systems, readings taken with the Modulus™ are not degraded by indirect fiber-optic transmission or crowded optical channels. Dedicated optical channeling ensures that the Modulus™ provides sensitivity and dynamic range on par with single-mode instruments.

Ease of Use

The Modulus™ is designed to be put into use straight from the box without the need to read a manual or obtain special training. To achieve this plug-and-play usability, the Modulus™ combines a color LCD display with an intuitive user interface. The interface makes running samples and viewing data fast and simple while also maintaining the flexibility needed for advanced or custom protocols.

Affordable Modularity

The Modulus™ is a modular instrument that fits easily into most budgets. Purchase the technology or modes that you need now and add onto the system later as your needs expand. For example, the Modulus™ can be purchased as a Luminometer, then Fluorescence and/or Absorbance Modules can be purchased and added later. There’s no service call or downtime. With the modular design, changing technologies is as easy as snapping in a module and restarting the instrument.

Minicell Adapter
For fluorescence measurements of sample volumes less than
250 µl, a minicell adapter is available as an optional accessory.

Lid Start
Adjust settings to start measurement immediately after the lid is closed.

Sample Formats
For luminescence measurements, the Modulus™ accepts 1.5-ml microcentrifuge tubes. For fluorescence and absorbance measurements, the Modulus accepts standard 10 x 10 mm cuvettes.

Touchscreen
The touchscreen allows simple navigation between screens for setting parameters, setting calibrations, and starting runs.

Troubleshooting
Easy access to HELP with the touch of a button.

Data Handling
The Modulus™ stores up to 18 calibrations. Data from the last 20 measurements are displayed on the color LCD screen. Optional accessories for easy data exportation include a PC Connect kit or thermal printer.

Fluorescence Applications

•     DNA/RNA Quantitation
•     Gene Expression Assays
•     Enzyme Assays
•     Protein Quantitation

Fluorescence

The Modulus™ with a Fluorescence Module is designed to deliver both high performance and user flexibility. To achieve high performance, each Fluorescence Module utilizes powerful light-emitting diodes (LEDs) as excitation sources. LEDs have very specific light-output profiles which closely match the excitation profile of commonly used fluorescent molecules. LED usage increases sensitivity by fully exciting the fluorophore and reducing non-specific light  leakage, a problem often found when using broad-spectrum light sources. Additionally, the highly-sensitive Modulus™ uses a 90-degree fluorescent design to minimize light scatter and lower background resulting in high sensitivity.

The Modulus™ as a fluorometer utilizes four easily exchangeable modules to measure the most popular fluorophores. In addition, custom modules can be made for non-standard applications.

Modulus Single Tube
Instrument Specifications

Detection Modes: Luminescence, Fluorescence, Absorbance
Read Type: Glow, Kinetic, Repeat
Sample Format: 10 x 10 mm cuvette,
100 - 250 µl minicell vial (optional), 1.5 ml microfuge tube (luminescence)
User Interface: Built-in PC, touchscreen navigation and operation
Data Output: Data displayed on screen or connect to PC (not included) via serial cable to download
External PC Requirements (optional): Windows 98 or later
Computer Interface: 100% ASCII format through a 9-pin RS-232 serial cable at 9600 baud rate
Power: 12 V 0.84 A Max
Auto Shutoff: Touch screen hibernates after 20 min of inactivity
Dimensions: 12.92” D x 10.22” W x 8.42” H (32.82 cm D x 26.52 cm W x 21.39 cm H)
Weight: 8.1 lbs (3.65 kg)
Operating Temperature: 60 - 105 ºF
(15 - 40 ºC)
Warranty: One year
Approvals: CE

Fluorescence Module
Specifications (user installable)

Light Source: Wavelength-matched LED
Detector: Photodiode
Wavelength Selection: Snap-in Fluorescence Modules
Fluorescence Modules:
P/N 9200-040 Blue (Ex 485 nm, Em 515 - 570 nm)
P/N 9200-041 UV (Ex 365 nm, Em 410 - 450 nm)
P/N 9200-042 Green (Ex 525 nm, Em 610 - 660 nm)
P/N 9200-043 Red (Ex 625 nm, Em 580 - 640 nm)
P/N 9200-044 UV-GFP (Ex 365 nm, Em 515 - 570 nm)
Detection Limit: 6 ppt fluorescein,
4.5 pg/100 µl DNA with PicoGreen® Dye
Linear Dynamic Range: 6 logs, assay dependent
Sample Format: 10 x 10 mm cuvette,
100 - 250 µl minicell vial (optional)
Read Out: Direct concentration or raw fluorescence
Calibration: 1 - 5 point calibration
Discrete Sample Average: Sample readings are averaged over 0.5 seconds to improve accuracy

For research use only. Not for use in diagnostic procedures. Modulus is a trademark of Turner BioSystems, Inc. All other trademarks are the sole property of their respective owners.

GSA Contract # GS 24F 0056N